Type 3 ILCs in Lung Disease

Type 3 ILCs in Lung Disease

Blog Article

The lungs represent a complex immune setting, balancing external environmental signals with a poised immune response that must protect from infection, mediate tissue repair, and maintain lung function.Innate lymphoid cells (ILCs) play a central role in tissue repair and homeostasis, and mediate protective immunity in a variety of mucosal tissues, including the lung.All three ILC subsets illumivein are present in the airways of both mice and humans; and ILC2s shown to have pivotal roles in asthma, airway hyper-responsiveness, and parasitic worm infection.The involvement of ILC3s in respiratory diseases is less well-defined, but they are known to be critical in homeostasis, infection and inflammation at other mucosal barriers, such as the gut.

Moreover, they are important players in the IL17/IL22 axis, which is key to lung health.In this review, we discuss the emerging role of ILC3s in the context of infectious and inflammatory lung diseases, with white feather tinsel a focus on data from human subjects.